Alright, Took me like 20 seconds to think about this and it seems like a good one...
Because that V is off of an indian dollar note, and everyone is saying that V will be in San Andreas, I believe that the protagonist will be a man of Indian decent. Woo Zi Mu perhaps is a good friend, or maybe a mortal antagonist of this new indian protagonist. Since Indians usually own casinos (sorry for the stereotyping), it'll set mainly in Las Venturas (like how TLAD was based in Alderney, and how TBOGT was based in Algonquin.
Then for the DLCs if they are any, one could be based in San Fierro where mob business is dealt. Because that the Caligulas Casino is owned by the Sindacco Family, and later the Leones and Forrelis, the Italian mob could do something along the lines that tie back to what CJ did at one time or just go back to the casino theme. Another DLC could be for Los Santos. Maybe a vigilante-like storyline that also ties in with the casino theme, maybe a prequel to the main story that leads up the the current events.
Anyone want to build up on this idea, or even agree? I think its a good prediction! Whats yours?